Sickle cell disease:causes, symptoms and treatment

Sickle cell disease is caused by change in the gene that tells the body to make haemoglobin in RBCs

It is often referred to as Sickle cell anemia. 

It is an autosome linked recessive trait that can be transmitted from parents to offspring if both are carriers of the gene. 

 The disease is controlled by a single pair of allele,HbA and HbS. 

Symptoms include anemia,pain,swelling of hands and feet,vision problems,delayed puberty.

 It is caused by the substitution of Glutamic acid by Valine at the sixth position of the beta globin chain of the haemoglobin

 As the condition can cause severe pain, treatment can include morphine.

New research has shown that a Christmas Bush plant may also help. 

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