Replications of Hepatitis A Virus(HAV).

 The viral replication cycle is vital for a virus to spread inside the body and cause disease.

 In HAV , replication requires specific interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases. 

 ZCCHC14—a particular protein that interacts with zinc and binds to RNA. 

Hepatitis A virus changes dramatically inside the human liver.   

 TENT4 is part of an RNA-modification process during cell growth.

HAV attacks TENT4 and uses it to replicate its own genome.  

Stopping of TENT4 recruitment could stop viral replication  

oral RG7834  is used to treat HAV. 

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